Trifexis for Dogs is one monthly chewable tablet that takes on three dangerous parasites. In addition to killing fleas and preventing infestations, Trifexis prevents heartworm disease, and treats and controls intestinal parasite infections in your pet. The three parasites Trifexis for Dogs attacks are hookworm, roundworm, and whipworm. Essentially, these parasites are worms that can thrive in your dog’s intestinal tract, causing any number of harmful diseases. Available from your veterinarian, Trifexis for Dogs is ideal for families with children or other pets. It involves no isolation of your pet or staining residue. For dogs with dermatological conditions that require topical therapy, Trifexis for Dogs is the perfect solution. It is designed for dogs and puppies 8 weeks of age or older with 5 pounds of body weight or greater.

Do I need a prescription to purchase this product? Yes.
What is the main flea killing ingredient (active ingredient)? Spinosad.
What are the flea sterilizing or additional ingredients? Milbemycin ( for additional parasites).
Intended Use: Dogs.
What is the youngest age I can use this on my pet? At least 8 weeks.
What is the weight requirements for use? At least 5 lbs.
Can I use on my pregnant or lactating (nursing) pet? Manufacturer recommends against use but not specifically labeled against use during this period.
Is this Waterproof or Water Resistant?: N/A.
How long before it starts to work? Starts killing fleas in 30 minutes.

How long until maximum effectiveness is reached? 100% fleas dead in 4 hours.
What other parasites does this kill, control, or repel? Hookworms, Roundworms, Whipworms & Heartworm.
How often should I apply or administer? Monthly.
How is it administered (Topically, orally, or other)? Oral (chewable, beef flavored).

• No need to isolate pet
• No staining residue
• Ideal for families with children or other pets
• Ideal for dogs with dermatological conditions requiring topical therapy
• Good for dogs that swim or bathe frequently

Directions for Use: Trifexis is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes.

Administer Trifexis with food for maximum effectiveness. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of Trifexis with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations. If vomiting occurs within an hour of administration, redose with another full dose.

Heartworm Prevention: Trifexis should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure and continuing until at least 3 months after the dog’s last seasonal exposure to mosquitoes. Trifexis may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of Trifexis should be given within a month of the last dose of the former medication.

Flea Treatment and Prevention: Treatment with Trifexis may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with Trifexis should continue the entire year without interruption. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.

Intestinal Nematode Treatment and Control: Trifexis provides treatment and control of roundworms, hookworms and whipworms. Dogs may be exposed to and can become infected with roundworms, whipworms and hookworms throughout the year, regardless of season or climate.

Our mission: We make life sciences work better for people by transforming animal protein production and companion animal care.

Making life sciences work better for people starts with a belief that everyone, everywhere should have enough to eat. And a belief that pets should live long, healthy lives while building a strong bond with their owners.

These beliefs drive the innovation that transforms animal health and well-being. These beliefs shape Elanco’s vision of food and companionship enriching life.